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Search Results to Vladimir Lupashin

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Lupashin, Vladimir

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Our laboratory is interested in understanding the molecular mechanisms responsible for the generation and maintenance of intra-cellular membrane-bounded compartments. In all eukaryotic cells intracellular membrane trafficking is critical for a range of important cellular functions including protein secretion, post-translational modifications, cell signalling, cell polarization, and cell maintenance. Defects in membrane trafficking can underline, or even exacerbate, a number of human diseases including cancer, diabetes mellitus, Alzheimer’s, cystic fibrosis, Hermansky-Pudlak syndrome and Congenital Disorders of Glycosylation. Our research directed towards the understanding of the basic mechanisms of intracellular vesicular trafficking using both yeast and mammalian tissue culture cell model systems. Our lab played a principal role in the discovery of a novel vesicle tethering factors, published more than 60 original papers in high-profile journals, including Journal of Cell Biology, PNAS, Science, Journal of Neuroscience, Molecular Biology of Cell and Nature Communications. My current research has been continuously supported by grants from both NSF and NIH. We have pioneered the functional analysis of the Conserved Oligomeric Golgi (COG), an evolutionarily conserved complex of eight gene products, each of which is critical for the membrane trafficking and protein modifications in the Golgi apparatus. The COG complex interacts with core fusion machinery components including SNAREs, SM proteins, Rabs, coiled-coil tethers and COPI coat to organize specific docking and fusion of transport intermediates with their acceptor membrane. By using state of the art biochemical, genetic and microscopy approaches (including mass-spectrometry, electron and super-resolution microscopy, CRISPR directed gene editing techniques) we would like to determine how the key components of intracellular membrane trafficking machinery work together to direct efficient protein trafficking in human cells in health and disease.

One or more keywords matched the following items that are connected to Lupashin, Vladimir

Item Type	Name
Academic Article	Golgi tethering factors.
Academic Article	Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex.
Academic Article	Role of tethering factors in secretory membrane traffic.
Academic Article	COG8 deficiency causes new congenital disorder of glycosylation type IIh.
Academic Article	[The nature of N-terminal signal sequence determines the type of intracellular distribution and effectiveness of export of human growth hormone in Saccharomyces cerevisiae].
Academic Article	Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability.
Academic Article	[Localization of acid phosphatase in Saccharomyces cerevisiae and its export into culture media depends on the type of the N-terminal signal peptide].
Academic Article	Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter.
Academic Article	Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation.
Academic Article	Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells.
Academic Article	Chlamydia trachomatis hijacks intra-Golgi COG complex-dependent vesicle trafficking pathway.
Academic Article	[Cell wall permeability and export of proteins into the culture broth of Saccharomyces cerevisiae].
Academic Article	Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Academic Article	Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
Academic Article	Identification of a novel secreted glycoprotein of the yeast Saccharomyces cerevisiae stimulated by heat shock.
Academic Article	The COG complex, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin.
Academic Article	Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs.
Academic Article	COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Academic Article	Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic.
Academic Article	COG complexes form spatial landmarks for distinct SNARE complexes.
Academic Article	The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.
Academic Article	Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.
Academic Article	Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery.
Academic Article	Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.
Academic Article	The Golgi puppet master: COG complex at center stage of membrane trafficking interactions.
Academic Article	Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking.
Academic Article	COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Academic Article	t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase.
Academic Article	Fluorescent microscopy as a tool to elucidate dysfunction and mislocalization of Golgi glycosyltransferases in COG complex depleted mammalian cells.
Academic Article	Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.
Academic Article	Assembly of the ER to Golgi SNARE complex requires Uso1p.
Academic Article	Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery.
Academic Article	[A new secreted protein from Saccharomyces cerevisiae, stimulated by heat shock].
Academic Article	Biochemical requirements for the targeting and fusion of ER-derived transport vesicles with purified yeast Golgi membranes.
Academic Article	Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p.
Academic Article	Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF).
Academic Article	The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.
Concept	Bacterial Proteins
Concept	Microtubule-Associated Proteins
Concept	Carrier Proteins
Concept	Fungal Proteins
Concept	DNA-Binding Proteins
Concept	Chromosomal Proteins, Non-Histone
Concept	Membrane Proteins
Concept	Luminescent Proteins
Concept	Protein Subunits
Concept	Molecular Motor Proteins
Concept	Proteins
Concept	Protein Conformation
Concept	Protein Processing, Post-Translational
Concept	Plant Proteins
Concept	GTP-Binding Proteins
Concept	Recombinant Proteins
Concept	Cation Transport Proteins
Concept	rab GTP-Binding Proteins
Concept	Protein Structure, Quaternary
Concept	Escherichia coli Proteins
Concept	Protein Binding
Concept	Serotonin Plasma Membrane Transport Proteins
Concept	Protein Transport
Concept	Proto-Oncogene Proteins c-myc
Concept	Protein Interaction Maps
Concept	Protein Multimerization
Concept	SNARE Proteins
Concept	Protein Stability
Concept	Green Fluorescent Proteins
Concept	Nerve Tissue Proteins
Concept	Saccharomyces cerevisiae Proteins
Concept	Heat-Shock Proteins
Concept	Qc-SNARE Proteins
Concept	GTPase-Activating Proteins
Concept	Intracellular Signaling Peptides and Proteins
Concept	Cell Cycle Proteins
Concept	Protein Structure, Secondary
Concept	Membrane Transport Proteins
Concept	rab4 GTP-Binding Proteins
Concept	Coat Protein Complex I
Concept	Protein Structure, Tertiary
Concept	Protein Sorting Signals
Concept	Qa-SNARE Proteins
Concept	Qb-SNARE Proteins
Concept	Structural Homology, Protein
Concept	Munc18 Proteins
Concept	Dystrophin-Associated Proteins
Concept	R-SNARE Proteins
Concept	Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Concept	Adaptor Proteins, Vesicular Transport
Concept	Recombinant Fusion Proteins
Concept	Vesicular Transport Proteins
Academic Article	Mini-Review: Role of the Conserved Oligomeric Golgi (COG) complex in protein glycosylation
Academic Article	Identification and characterization of novel proteins involved in the regulation of SNARE-complex assembly
Academic Article	Yeast COG complex, a Ypt1 effector required for retrograde intra-Golgi trafficking COG interacts with the Golgi SNAREs and with COPI vesicle coat proteins
Academic Article	Extracellular enzymes of microorganisms
Academic Article	The COG Complex-mediated Docking of intra-Golgi Vesicles is Essential for Normal Protein Glycosylation
Academic Article	The COG complex interacts with the t-SNARE Syntaxin5 to direct trafficking of recyling intra-Golgi vesicles that is essential for normal protein glycosylation
Academic Article	Serotonin Regulates the Plasma Membrane Expression of Serotonin Transporter Protein Via its Interactions with Rab4
Academic Article	The COG Complex-mediated Recyling of Golgi Enzymes is Essential for Normal Protein Glycosylation
Academic Article	Macromolecules in functioning cell
Academic Article	The Conserved Oligomeric Golgi complex functional interaction with SNARE and Rab proteins
Academic Article	Protein Trafficking: Mechanisms and Regulations
Academic Article	Localization and characterization of yeast secretory proteins stimulated by heat shock
Academic Article	The role of glycosylation in protein secretion
Academic Article	Optimal conditions for homologic and heterologic protein export by S. cerevisiae
Academic Article	Glycosylation of secreted proteins in yeast
Academic Article	Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.
Academic Article	Expression of functional Myc-tagged conserved oligomeric Golgi (COG) subcomplexes in mammalian cells.
Academic Article	The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection.
Academic Article	COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.
Academic Article	Creating Knockouts of Conserved Oligomeric Golgi Complex Subunits Using CRISPR-Mediated Gene Editing Paired with a Selection Strategy Based on Glycosylation Defects Associated with Impaired COG Complex Function.
Academic Article	Manganese-induced turnover of TMEM165.
Academic Article	Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.
Academic Article	Galactose Supplementation in Patients With TMEM165-CDG Rescues the Glycosylation Defects.
Academic Article	A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.
Academic Article	Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking.
Academic Article	The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.
Academic Article	Membrane detachment is not essential for COG complex function.
Academic Article	More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects.
Academic Article	Detailed Analysis of the Interaction of Yeast COG Complex.
Grant	Super-Resolution Light Microscope at University of Arkansas for Medical Sciences
Grant	Characterization of mammalian COG complex-interacting Golgi trafficking machinery
Grant	Structural and functional analysis of SEC 34 Protein complex
Academic Article	Dissection of TMEM165 function in Golgi glycosylation and its Mn2+ sensitivity.
Academic Article	Fetal bovine serum impacts the observed N-glycosylation defects in TMEM165 KO HEK cells.
Academic Article	Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread.
Academic Article	Golgi inCOGnito: From vesicle tethering to human disease.
Academic Article	Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma.
Academic Article	Proteoglycan synthesis in conserved oligomeric Golgi subunit deficient HEK293T cells is affected differently, depending on the lacking subunit.
Academic Article	The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery.
Academic Article	Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation.
Academic Article	Insights into the regulation of cellular Mn2+ homeostasis via TMEM165.
Academic Article	GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins.
Academic Article	Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System.
Academic Article	Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines.
Academic Article	Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles.
Academic Article	A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation.
Academic Article	Syntaxin-5's flexibility in SNARE pairing supports Golgi functions.
Academic Article	Biallelic missense variants in COG3 cause a congenital disorder of glycosylation with impairment of retrograde vesicular trafficking.

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GTP Binding Proteins